IkappaB kinase activity [GO_0008384]

Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.

IkappaB kinase activity

ID: GO_0008384

Class

Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.

Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.

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Classification

protein serine/threonine kinase activity

Relationships

is part of: I-kappaB phosphorylation

Alternative Names

Synonym	Scope	Reference
IKK	related synonym	2.7.11.10
IKBKA	related synonym	2.7.11.10
inhibitor of NFkappaB kinase activity	related synonym	2.7.11.10
inhibitor of NF-kappaB kinase activity	related synonym	2.7.11.10
IKBKB	related synonym	2.7.11.10
IKK-2	related synonym	2.7.11.10
IKK-1	related synonym	2.7.11.10
STK12	related synonym	2.7.11.10
ATP:IkappaB protein phosphotransferase activity	related synonym	2.7.11.10
TBK1	related synonym	2.7.11.10
CHUK	related synonym	2.7.11.10
TANK-binding kinase 1 activity	narrow synonym	2.7.11.10

References

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"color:#ff79c6">"types": [ "Entity", "Class" ], "short_form": "GO_0007252", "unique_facets": [ "Class" ], "label": "I-kappaB phosphorylation" } } ], "xrefs": [], "anatomy_channel_image": [], "pub_syn": [ { "synonym": { "scope": "has_narrow_synonym", "label": "TANK-binding kinase 1 activity", "type": "" }, "pub": { "core": { "symbol": "", "iri": "http://flybase.org/reports/Unattributed", "types": [ "Entity", "Individual", "pub" ], "short_form": "Unattributed", "unique_facets": [ "pub" ], "label": "" }, "FlyBase": "", "PubMed": "", "DOI": "" } } ], "def_pubs": [] }

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